In 1994, Dr. Léguillette graduated from the ENVA (Ecole Nationale Vétérinaire d’Alfort) in Paris, France. After that, he completed an internship and a residency in equine internal medicine at the Faculty of Veterinary Medicine (FMV) of the Université de Montréal. From 1998 to 2001 Dr. Leguillette was hired as a clinician and lecturer in equine internal medicine. During that time, he obtained the status of diplomate of the American College of Veterinary Internal Medicine (ACVIM) in 2000 and in 2001 he earned his M.Sc. for a new treatment for horses affected with heaves.

In 2006, at the renowned Meakins-Christie Laboratories at McGill University, Dr. Léguillette completed a PhD on airway smooth muscle in human patients with asthma. Dr. Léguillette has been involved with the University of Calgary Faculty of Veterinary Medicine (UCVM) since its early days in 2006 - he is now an Associate Professor and Interim Department Head of the department of Veterinary Clinical and Diagnostic Sciences. At the UCVM he has developed a research program on inflammatory lung diseases, like heaves, and IAD (Inflammatory Airway Disease), as well as in equine sports medicine with a focus on cardio-respiratory physiology.

He has performed many clinical trials and field studies in Calgary, Alberta on the treatment of heaves and IAD, as well as on exercise physiology of show jumpers and chuckwagon horses. Dr. Léguillette is practicing as a UCVM equine internal medicine specialist at Moore Equine in Balzac, Alberta.